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“Because it stimulates the body’s own growth hormone production, dosing needs to stay within physiologic limits to avoid excess IGF-1.” If levels climb too high, she notes, you might get symptoms such as fluid retention, joint stiffness, carpal tunnel–like numbness, or mild insulin resistance, though these effects are uncommon with conservative dosing and regular monitoring

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2022;13 doi: 10.3389/fendo.2022.927859